Ethanol Fermentation Simulation

Enhancing the mechanistic understanding of ethanol fermentation kinetics is the principal educational objective
of FermAxiom LLC. We view providing free topic-specific access to an integrated simulation suite — coupling
a steady-state Medium Calculator with a dynamic Time-Course Simulator — as central to the enhanced
comprehension of anaerobic Saccharomyces cerevisiae performance across the four operating
regimes used in industrial practice. Batch fermentation runs to completion on a single charge of
substrate. Semi-batch operation introduces sequential substrate additions to extend exponential
growth and lift final ethanol titer. Fed-batch operation feeds substrate continuously to maintain
a target glucose set-point and suppress Crabtree-driven byproducts.
Continuous fermentation holds the bioreactor at steady state by matching feed and
bleed flows. Glucose, biomass, ethanol, glycerol, and CO₂ trajectories are
computed for each regime with calibrated treatment of ergosterol dilution,
ethanol toxicity, and Liebig's-minimum nutrient coupling. In depth
application guidance is further available under
Industrial Bioprocess Technology Platforms and E-Modules