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C6 BioProcess Validation – FermAxiom LLC
Industrial Services / Service Line 2 of 5

C6 BioProcess Validation

Validation establishes — across every unit operation — that your plant performs to its
documented targets. FermAxiom characterizes the full C6 process, from material balance through
upstream processing, propagation, and fermentation to downstream recovery, pairing Service Team
diagnostics with R&D Analytics Group bench- and pilot-scale verification.

Ongoing Scope

  • Full material-balance validation — corn, chemical inputs, water quality
  • Upstream processing — milling, cook, primary & secondary liquefaction
  • Propagation & fermentation growth and metabolic kinetics
  • Downstream — beerwell, total yield, recyclables, commercial products

What You Receive

  • Unit-by-unit validation reports against documented targets
  • Propagation & fermentation matrix analysis
  • Laboratory scale-down verification of propagation & fermentation
  • Statistical performance analysis with corrective guidance

Outcomes

  • A documented, defensible performance baseline
  • Confidence in unit-operation and yield targets
  • Early detection of drift and contamination risk
  • A validated foundation for optimization
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Validation – Scope & Coverage (DNN)
ValidationETHANOL BIOPROCESS · SCOPE OF WORK

FermAxiom's full-plant validation plan — characterizing every unit operation against documented targets through the Focused Ethanol Matrix Analysis Platform, independent of any ingredient producer or product.

●full scope    ○limited scope

Full verification of the incoming streams that set the plant's baseline.

  • ●Agricultural feedstocks qualification
  • ●Total chemical inputs
  • ●Process streams qualification
  • ○Plant emissions

Review of the milling, cook, and liquefaction train ahead of fermentation.

  • ○Bioprocess streams & chemical balance
  • ○Milling process review
  • ○Cook process quantification
  • ○Primary liquefaction quantification
  • ○Secondary liquefaction quantification

Comprehensive validation of the propagation train across kinetics, yield, and scale-down.

  • ●Standard operating procedures review
  • ●Statistical analysis – propagation performance
  • ●Growth & metabolic kinetics analysis
  • ●Yeast inoculum quantification
  • ●Yield-impact & efficiency determination
  • ●Medium chemical quantification & equipment documentation
  • ●Laboratory scale-down verification & matrix analysis
  • ●Unit operation update
  • ○Medium chemical qualification

The same full validation applied across the fermentation train.

  • ●Standard operating procedures review
  • ●Statistical analysis – fermentation performance
  • ●Growth & metabolic kinetics analysis
  • ●Yield-impact & efficiency determination
  • ●Bioprocess equipment documentation
  • ●Laboratory scale-down verification & matrix analysis
  • ●Unit operation update
  • ○Total substrate & inhibitor quantification

Full quantification of recovery, yield, and co-products.

  • ●Beerwell quantification & qualification
  • ●Total yield analysis
  • ●Overall process efficiency analysis
  • ●Recyclables quantification & qualification
  • ●Commercial products analysis

On-site support, training, and independent verification across the campaign.

  • ●Technical training
  • ●Emergency issue resolution
  • ●Independent trial results verification
  • ○Quarterly site visit & analysis
  • ○Monthly site visit & analysis
  • ○Plant start-up & shut-down support
Process CoverageSCOPE DEPTH PER STAGE

Validation establishes full-plant performance against documented targets, with comprehensive reach across every unit operation — deepest in processing quantification, propagation, and fermentation.

Material Balance88%
Upstream Processing50%
Yeast Biomass Propagation96%
Ethanol Fermentation95%
Processing Quantification100%
Technical Support75%

Research scale-down verification (Service Plus, Optimization) and D-Optimal design modeling (Optimization) sit outside the Validation scope.