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C6 BioProcess Optimization – FermAxiom LLC
Industrial Services / Service Line 3 of 5

C6 BioProcess Optimization

Optimization is FermAxiom's top-tier engagement — building on full validation to actively lift
volumetric productivity, efficiency, and ethanol yield through statistically designed experimentation.
The R&D Analytics Group drives multi-variable surface-response and D-Optimal design modeling,
translating plant data into a prioritized, quantified improvement roadmap.

Ongoing Scope

  • Everything in BioProcess Validation, plant-wide
  • Total substrate & inhibitor quantification
  • Bioprocess streams & chemical balance across upstream
  • Plant start-up & shut-down support

What You Receive

  • D-Optimal design (DoE) modeling — propagation & fermentation
  • Multi-variable surface-response optimization
  • Quarterly on-site visits & analysis
  • Prioritized, quantified improvement roadmap

Outcomes

  • Higher volumetric productivity and ethanol yield
  • Improved unit operations and efficiency
  • Lower cost per gallon
  • Sustained, data-driven performance gains
Optimization – Scope & Coverage (DNN)
OptimizationETHANOL BIOPROCESS · SCOPE OF WORK

FermAxiom's top-tier plan — the full validation scope plus statistically designed experimentation (D-Optimal / surface-response) to actively lift volumetric productivity, efficiency, and ethanol yield. Delivered through the Focused Ethanol Matrix Analysis Platform, independent of any ingredient producer or product.

●full scope    ○limited scope

Full verification of the incoming streams that set the plant's baseline.

  • ●Agricultural feedstocks qualification
  • ●Total chemical inputs
  • ●Process streams qualification
  • ○Plant emissions

Complete quantification of the milling, cook, and liquefaction train.

  • ●Bioprocess streams & chemical balance
  • ●Milling process review
  • ●Cook process quantification
  • ●Primary liquefaction quantification
  • ●Secondary liquefaction quantification

Full-depth propagation coverage, extended with statistically designed experimentation.

  • ●Standard operating procedures review
  • ●Statistical analysis – propagation performance
  • ●Growth & metabolic kinetics analysis
  • ●Yeast inoculum quantification
  • ●Yield-impact & efficiency determination
  • ●Medium chemical quantification, qualification & equipment documentation
  • ●Research & laboratory scale-down verification
  • ●D-Optimal design modeling
  • ●Unit operation update

The same full-depth coverage and DoE modeling across the fermentation train.

  • ●Standard operating procedures review
  • ●Statistical analysis – fermentation performance
  • ●Growth & metabolic kinetics analysis
  • ●Yield-impact & efficiency determination
  • ●Total substrate & inhibitor quantification
  • ●Bioprocess equipment documentation
  • ●Research & laboratory scale-down verification
  • ●D-Optimal design modeling
  • ●Unit operation update

Full quantification of recovery, yield, and co-products.

  • ●Beerwell quantification & qualification
  • ●Total yield analysis
  • ●Overall process efficiency analysis
  • ●Recyclables quantification & qualification
  • ●Commercial products analysis

Full on-site support, training, and start-up / shut-down coverage.

  • ●Quarterly site visit & analysis
  • ●Technical training
  • ●Emergency issue resolution
  • ●Independent trial results verification
  • ●Plant start-up & shut-down support
  • ○Monthly site visit & analysis
Process CoverageSCOPE DEPTH PER STAGE

Optimization delivers full-depth coverage across every process stage, adding D-Optimal design modeling to drive measurable gains in productivity, efficiency, and ethanol yield.

Material Balance88%
Upstream Processing100%
Yeast Biomass Propagation100%
Ethanol Fermentation100%
Processing Quantification100%
Technical Support92%

Optimization is the only tier to include D-Optimal design modeling and full plant start-up / shut-down support.