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C6 BioProcess Optimization – FermAxiom LLC
Industrial Services / Service Line 3 of 5

C6 BioProcess Optimization

Optimization is FermAxiom's top-tier engagement — building on full validation to actively lift
volumetric productivity, efficiency, and ethanol yield through statistically designed experimentation.
The R&D Analytics Group drives multi-variable surface-response and D-Optimal design modeling,
translating plant data into a prioritized, quantified improvement roadmap.

Ongoing Scope

  • Everything in BioProcess Validation, plant-wide
  • Total substrate & inhibitor quantification
  • Bioprocess streams & chemical balance across upstream
  • Plant start-up & shut-down support

What You Receive

  • D-Optimal design (DoE) modeling — propagation & fermentation
  • Multi-variable surface-response optimization
  • Quarterly on-site visits & analysis
  • Prioritized, quantified improvement roadmap

Outcomes

  • Higher volumetric productivity and ethanol yield
  • Improved unit operations and efficiency
  • Lower cost per gallon
  • Sustained, data-driven performance gains
Optimization – Scope & Coverage (DNN)
OptimizationETHANOL BIOPROCESS · SCOPE OF WORK

FermAxiom's top-tier plan — the full validation scope plus statistically designed experimentation (D-Optimal / surface-response) to actively lift volumetric productivity, efficiency, and ethanol yield. Delivered through the Focused Ethanol Matrix Analysis Platform, independent of any ingredient producer or product.

full scope    limited scope

Full verification of the incoming streams that set the plant's baseline.

  • Agricultural feedstocks qualification
  • Total chemical inputs
  • Process streams qualification
  • Plant emissions

Complete quantification of the milling, cook, and liquefaction train.

  • Bioprocess streams & chemical balance
  • Milling process review
  • Cook process quantification
  • Primary liquefaction quantification
  • Secondary liquefaction quantification

Full-depth propagation coverage, extended with statistically designed experimentation.

  • Standard operating procedures review
  • Statistical analysis – propagation performance
  • Growth & metabolic kinetics analysis
  • Yeast inoculum quantification
  • Yield-impact & efficiency determination
  • Medium chemical quantification, qualification & equipment documentation
  • Research & laboratory scale-down verification
  • D-Optimal design modeling
  • Unit operation update

The same full-depth coverage and DoE modeling across the fermentation train.

  • Standard operating procedures review
  • Statistical analysis – fermentation performance
  • Growth & metabolic kinetics analysis
  • Yield-impact & efficiency determination
  • Total substrate & inhibitor quantification
  • Bioprocess equipment documentation
  • Research & laboratory scale-down verification
  • D-Optimal design modeling
  • Unit operation update

Full quantification of recovery, yield, and co-products.

  • Beerwell quantification & qualification
  • Total yield analysis
  • Overall process efficiency analysis
  • Recyclables quantification & qualification
  • Commercial products analysis

Full on-site support, training, and start-up / shut-down coverage.

  • Quarterly site visit & analysis
  • Technical training
  • Emergency issue resolution
  • Independent trial results verification
  • Plant start-up & shut-down support
  • Monthly site visit & analysis
Process CoverageSCOPE DEPTH PER STAGE

Optimization delivers full-depth coverage across every process stage, adding D-Optimal design modeling to drive measurable gains in productivity, efficiency, and ethanol yield.

Material Balance88%
Upstream Processing100%
Yeast Biomass Propagation100%
Ethanol Fermentation100%
Processing Quantification100%
Technical Support92%

Optimization is the only tier to include D-Optimal design modeling and full plant start-up / shut-down support.